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In this podcast, Dr. Miriam Kaufman, Professor of Paediatrics and Adolescent Consultant to The Transplant Centre at The Hospital for Sick Children/University of Toronto, discusses substance use, sexuality and non-adherence in adolescent solid organ transplant recipients. She emphasizes the importance of understanding the context of their behavior - their developing identity, emotional awareness and cognitive sophistication; and provides practical advice for physicians about how to approach and give advice around some of the key issues.