Originally aired on Tuesday, May 19th, 2020, from 2:00 PM ET to 3:00 PM ET • Hosted by the Community of Transplant Scientists (COTS)
"Signaling through the Inhibitory Fc Receptor FcgRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity"
(Immunity. 2020 Jan 14;52(1):136-150.e6. doi: 10.1016/j.immuni.2019.12.006.)
In this article:
"Effector CD8+ T cells are important mediators of adaptive immunity, and receptor-ligand interactions that regulate their survival may have therapeutic potential. Here, [the authors] identified a subset of effector CD8+ T cells that expressed the inhibitory fragment crystallizable (Fc) receptor FcγRIIB following activation and multiple rounds of division... Increased expression of FcγRIIB correlated with freedom from rejection following withdrawal from immunosuppression in a clinical trial of kidney transplant recipients. [Findings demonstrated] a cell-intrinsic coinhibitory function of FcγRIIB in regulating CD8+ T cell immunity."
Anna Morris, PhD • Emory University, Atlanta, GA
Mandy Ford, PhD • Emory University, Atlanta, GA
Olivia Martinez, PhD • Stanford University, Stanford, CA