2025 Report of the STAR Working Group on donor-derived cell-free DNA: Establishing analytical validity as the basis for appropriate and effective clinical utilization
2025 Report of the STAR Working Group on donor-derived cell-free DNA: Establishing analytical validity as the basis for appropriate and effective clinical utilization
AST's TCC COP welcomes Drs. Valenzuela, Farr, Nikolova, Schinstock, and Tambur to discuss the STAR Working Group's 2025 report on donor-derived cell-free DNA and the basis for appropriate and effective clinical utilization.
- 2:00 PM - 3:00 PM EDT
- Virtual
"2025 Report of the Sensitization in Transplantation: Assessment of Risk Working Group on donor-derived cell-free DNA: Establishing analytical validity as the basis for appropriate and effective clinical utilization"
(Am J Transplant. 2026 Jan;26(1):20-31. doi: 10.1016/j.ajt.2025.08.036. Epub 2025 Sep 10.)
In this featured American Journal of Transplantation (AJT) article:
A working group under the Sensitization in Transplantation: Assessment of Risk initiative was established in 2023 to develop guidelines for analytical and clinical validity of lab-based testing for donor-derived cell-free DNA (dd-cfDNA). Measurement of dd-cfDNA as a minimally invasive marker of allograft injury has become more widely used over the last few years... The goal of this work group was to review and analyze technical and biological variables and clinical settings that could contribute to disparities in results, which will ultimately influence clinical validity and utility. High-quality, standardized decentralized dd-cfDNA testing is the essential prerequisite for conducting real-world evidence-generating multicenter studies to establish the appropriate context of use for this promising assay. Read more.
This session will also reference the "Sensitization in organ transplantation: Assessment of Risk (STAR) 2025 meeting group report" (Am J Transplant. 2026 Jan 8:S1600-6135(25)03456-2. doi: 10.1016/j.ajt.2025.12.286.).
Speaker:
Nicole Valenzuela, PhD • MaineHealth/NoreDx, Scarborough, ME
Moderators:
Maryjane Farr, MD, MSc, FAST • University of Pennsylvania, Philadelphia, PA
Andriana Nikolova, MD, PhD • Cedars-Sinai Medical Center, Los Angeles, CA
Discussants:
Carrie Schinstock, MD • Mayo Clinic, Rochester, MN
Anat Tambur, DMD, PhD, D(ABHI), FAST • Northwestern University, Chicago, IL
This AST Journal Club Series webinar is hosted by the AST Thoracic and Critical Care Community of Practice (TCC COP). All AST Journal Clubs are free but registration is required to attend live.
To learn more about the American Journal of Transplantation (AJT), visit www.amjtransplant.org.
More information on the AST/ASHI Sensitization in Transplantation: Assessment of Risk (STAR) Working Group, including recordings of past Working Group reports, can be found here.
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