BK Polyomavirus (BKPyV) Serotype-Specific Antibody Responses in Blood Donors and Kidney Transplant Recipients with and without new-onset BKPyV-DNAemia: A Swiss Transplant Cohort Study
BK Polyomavirus (BKPyV) Serotype-Specific Antibody Responses in Blood Donors and Kidney Transplant Recipients with and without new-onset BKPyV-DNAemia: A Swiss Transplant Cohort Study
AST's IDCOP welcomes Drs. Hillenbrand, Hirsch, Limaye, and Ni to discuss BK polyomavirus (BKPyV) as a cause of premature renal failure of kidney transplant recipients (KTRs) and immunization pretransplant or early posttransplant.
- 11:00 AM - 12:00 PM EDT
- Virtual
"BK Polyomavirus (BKPyV) Serotype-Specific Antibody Responses in Blood Donors and Kidney Transplant Recipients with and without new-onset BKPyV-DNAemia: A Swiss Transplant Cohort Study" (Am J Transplant. 2024 Nov 22:S1600-6135(24)00707-X. doi: 10.1016/j.ajt.2024.11.019.)
In this featured American Journal of Transplantation (AJT) article:
BK polyomavirus (BKPyV) causes premature renal failure in 10% to 30% of kidney transplant recipients (KTRs). Current guidelines recommend screening for new-onset BKPyV-DNAemia/nephropathy and reducing immunosuppression to regain BKPyV-specific immune control. Because BKPyV encompasses 4 major genotype (gt)-encoded serotypes (st1,-2,-3,-4), st-specific antibodies may inform the risk and course of BKPyV-DNAemia/nephropathy. [The authors] analyzed plasma from 399 blood donors (BDs) and 428 KTRs (134 KTR-cases with BKPyV-DNAemia, 294 KTR-controls)... [and found] BKPyV st-specific antibody levels at transplantation might reflect gt/st-BKPyV-specific immunity clearing or preventing BKPyV-DNAemia in KTR-cases or KTR-controls, respectively. Accordingly, active or passive immunization may be most efficient pretransplant or early posttransplant. Read more.
Speaker:
- Caroline Hillenbrand, PhD Student • University of Basel, Basel, Switzerland
Moderators:
- Ajit Limaye, MD • University of California San Francisco, San Francisco, CA
- Bin Ni, MD, PhD • Duke University Medical Center, Durham, NC
Discussant:
- Professor Hans H. Hirsch, MD, MSc, FAST • University of Basel, Basel, Switzerland
This AST Journal Club Series webinar is hosted by AST's Infectious Disease Community of Practice (IDCOP). All AST Journal Clubs are free but registration is required to attend live. To learn more about the American Journal of Transplantation (AJT), visit www.amjtransplant.org.
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