CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4+ T cell immunity is dependent on an intrinsic stem-like program
AST's COTS welcomes Drs. Chen, Li, and Fribourg to discuss findings for a stem-like program that governs the CD4+ T cell response in transplantation models.
- 2:00 PM - 3:00 PM EDT
- Virtual, as part of the AST Journal Club Series.
"CD4+ T cell immunity is dependent on an intrinsic stem-like program"
(Nat Immunol. 2024 Jan;25(1):66-76. doi: 10.1038/s41590-023-01682-z. Epub 2024 Jan 2.)
In this article:
CD4+ T cells are central to various immune responses, but the molecular programs that drive and maintain CD4+ T cell immunity are not entirely clear. Here [the authors] identify a stem-like program that governs the CD4+ T cell response in transplantation models... [The authors'] findings unravel a stem-like program that controls the self-renewal capacity and effector differentiation potential of CD4+ TEP cells and have implications for T cell-related immunotherapies. Read more.
Speaker:
- Wenhao Chen, PhD • Houston Methodist Hospital, Houston, TX
Moderator:
- Miguel Fribourg, PhD • Icahn School of Medicine at Mount Sinai, New York, NY
Discussant:
- Xian Li, MD, PhD • Houston Methodist Hospital, Houston, TX