COTS invites the authors to discuss why colonized organs have poorer outcomes than sterile organs in the clinic.
"Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants"
(J Clin Invest. 2022 Sep 1;132(17):e153403. doi: 10.1172/JCI153403.)
In this article:
Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts. Strikingly, barrier organs colonized with microbiota have significantly shorter half-lives than non-barrier transplanted organs, even in immunosuppressed hosts. [The authors] previously demonstrated that skin allografts monocolonized with the common human commensal Staphylococcus epidermidis (S.epi) are rejected faster than germ-free (GF) allografts in mice because the presence of S.epi augments the effector alloimmune response locally in the graft. Here, [the authors] tested whether host immune responses against graft-resident commensal microbes, including S.epi, can damage colonized grafts independently from the alloresponse... The dual effects of host-versus-commensal and host-versus-allograft responses may partially explain why colonized organs have poorer outcomes than sterile organs in the clinic.
Speaker:
- Isabella Pirozzolo • Columbia University Vagelos College of Physicians and Surgeons, New York, NY
Discussant:
- Maria-Luisa Alegre, MD, PhD • University of Chicago, Chicago, IL
Moderator:
- Andrew Wells, PhD • University of Pennsylvania, Philadelphia, PA
Hosted by AST's Community of Transplant Scientists (COTS). All AST Journal Clubs, and featured AST/AJT Journal Clubs, are free but registration is required to attend live.