Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction
Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction
AST's COTS welcomes Drs. Zhanzak, Larsen, Kissick, and Fribourg to discuss how targeting a narrow range of donor antigens may prevent DSA formation and improve transplant outcomes.
- 2:00 PM - 3:00 PM EDT
- Virtual
"Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction"
(Immunity. 2025 Feb 11;58(2):448-464.e6. doi: 10.1016/j.immuni.2025.01.008. Epub 2025 Jan 30.)
In this article:
Antibodies against the donor human leukocyte antigen (HLA) molecules drive late transplant failure, with HLA-DQ donor-specific antibodies (DSAs) posing the highest rejection risk. Here, [the authors] investigated the role of indirect CD4+ T cell epitopes-donor-derived peptides presented by recipient major histocompatibility complex (MHC) class II-in DSA formation. Antigen mapping of samples from HLA-DQ DSA-positive kidney and heart transplant recipients revealed two polymorphic hotspots in donor HLA-DQ that generated alloreactive peptides... Systemic delivery of high-dose donor H2-Kd peptides combined with CTLA4-Ig reduced the frequencies of Kd287+ CD4+ T cells and DSA formation. Thus, targeting a narrow range of donor antigens may prevent DSA formation and improve transplant outcomes. Read more.
Speaker:
Zhuldyz Zhanzak, PhD Candidate • Emory University, Atlanta, GA
Moderator:
Miguel Fribourg, PhD • Icahn School of Medicine at Mount Sinai, New York, NY
Discussants:
- Christian Larsen, MD, PhD • Emory University, Atlanta, GA
- Haydn Kissick, PhD • Emory University, Atlanta, GA
This AST Journal Club Series webinar is hosted by AST's Community of Transplant Scientists (COTS). All AST Journal Clubs are free but registration is required to attend live.
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