Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
AST's COTS invites Drs. Rosado-Sánchez, Krummey, and Levings to discuss CAR-Treg biology and the important implications for the design of CARs for clinical use in Tregs.
- 2:00 PM - 3:00 PM EST
- Virtual, as part of the AST Journal Club Series.
Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
(JCI Insight. 2023 Oct 9;8(19):e167215. doi: 10.1172/jci.insight.167215.)
In this article:
Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encoding CARs. However, these models could underrepresent interactions between CAR-Tregs, antigen-presenting cells (APCs), and donor-specific Abs. [The authors] generated Tregs expressing HLA-A2–specific CARs with different costimulatory domains and compared their function in vitro and in vivo using an immunocompetent model of transplantation... This study reveals a dimension of CAR-Treg biology and has important implications for the design of CARs for clinical use in Tregs. Read more.
Speaker:
- Isaac Rosado-Sánchez, PhD • University of British Columbia, BC Children’s Hospital Research Institute, Vancouver, BC
Moderator:
- Scott Krummey, MD, PhD • Johns Hopkins University School of Medicine, Baltimore, MD
Panelist:
- Megan Levings, PhD • University of British Columbia, BC Children’s Hospital Research Institute, Vancouver, BC
Sponsored by AST's Community of Transplant Scientists (COTS)
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