Scheduled for Tuesday, May 19th, 2020, from 2:00 PM ET to 3:00 PM ET • Hosted by the Community of Transplant Scientists (COTS)

"Signaling through the Inhibitory Fc Receptor FcgRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity"
(Immunity. 2020 Jan 14;52(1):136-150.e6. doi: 10.1016/j.immuni.2019.12.006.)

In this article:
"Effector CD8+ T cells are important mediators of adaptive immunity, and receptor-ligand interactions that regulate their survival may have therapeutic potential. Here, [the authors] identified a subset of effector CD8+ T cells that expressed the inhibitory fragment crystallizable (Fc) receptor FcγRIIB following activation and multiple rounds of division... Increased expression of FcγRIIB correlated with freedom from rejection following withdrawal from immunosuppression in a clinical trial of kidney transplant recipients. [Findings demonstrated] a cell-intrinsic coinhibitory function of FcγRIIB in regulating CD8+ T cell immunity."

Speakers:
Anna Morris, PhD • Emory University, Atlanta, GA
Mandy Ford, PhD • Emory University, Atlanta, GA

Moderator:
Olivia Martinez, PhD • Stanford University, Stanford, CA

Live webinars in the AST/AJT Journal Club series are open to both members and non-members. Pre-registration is required.

Thursday, March 12, 2020 from 2:00 PM ET to 3:00 PM ET • Hosted by the Community of Transplant Scientists (COTS)

"Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts."
(J Clin Invest. 2020;130(1):287-294. doi: 10.1172/JCI125773.)

In this article:
"Using mouse islet and kidney transplantation models, imaging cytometry, and 2-photon intravital microscopy, [the authors] demonstrate extensive cross-dressing of intragraft host DCs with donor MHC-peptide complexes that occurred early after transplantation, whereas host DCs presenting donor antigen via the indirect pathway were rare. Cross-dressed DCs stably engaged TCRtransgenic effector CD8+ T cells that recognized donor antigen and were sufficient for sustaining acute rejection. In the chronic kidney rejection model, cross-dressing declined over time but was still conspicuous 8 weeks after transplantation. [The authors] conclude that crossdressing of host DCs with donor MHC molecules is a major antigen presentation pathway driving effector T cell responses within allografts."

Speakers:
Martin Oberbarnscheidt, MD, PhD • University of Pittsburgh, Pittsburgh, PA

Moderator:
Olivia Martinez, PhD • Stanford University, Stanford, CA

AST/AJT Journal Clubs are free to both AST and non-AST members, but registration is required. Please feel free to share the registration link with colleagues and fellows who may be interested in the discussion.

Hosted by Community of Basic Scientists

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

Speaker: Christopher Jewell, PhD • University of Maryland
Moderator: Jonathan Bromberg, MD, PhD • University of Maryland