Originally aired on Thursday, March 12, 2020 • Hosted by the Community of Transplant Scientists (COTS)
"Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts."
(J Clin Invest. 2020;130(1):287-294. doi: 10.1172/JCI125773.)
In this article:
"Using mouse islet and kidney transplantation models, imaging cytometry, and 2-photon intravital microscopy, [the authors] demonstrate extensive cross-dressing of intragraft host DCs with donor MHC-peptide complexes that occurred early after transplantation, whereas host DCs presenting donor antigen via the indirect pathway were rare. Cross-dressed DCs stably engaged TCRtransgenic effector CD8+ T cells that recognized donor antigen and were sufficient for sustaining acute rejection. In the chronic kidney rejection model, cross-dressing declined over time but was still conspicuous 8 weeks after transplantation. [The authors] conclude that crossdressing of host DCs with donor MHC molecules is a major antigen presentation pathway driving effector T cell responses within allografts."
Martin Oberbarnscheidt, MD, PhD • University of Pittsburgh, Pittsburgh, PA
Olivia Martinez, PhD • Stanford University, Stanford, CA
ISSUE: We have discovered an issue with the recorded audio for this presentation. We are working to see if the live audio can be fully recovered. If this is not possible, we will work with the presenters to see if we can provide supplementary information related to the presentation. We apologize for the inconvenience.