"Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts"

Originally aired on Thursday, March 12, 2020 • Hosted by the Community of Transplant Scientists (COTS)

"Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts."
(J Clin Invest. 2020;130(1):287-294. doi: 10.1172/JCI125773.)

In this article:
"Using mouse islet and kidney transplantation models, imaging cytometry, and 2-photon intravital microscopy, [the authors] demonstrate extensive cross-dressing of intragraft host DCs with donor MHC-peptide complexes that occurred early after transplantation, whereas host DCs presenting donor antigen via the indirect pathway were rare. Cross-dressed DCs stably engaged TCRtransgenic effector CD8+ T cells that recognized donor antigen and were sufficient for sustaining acute rejection. In the chronic kidney rejection model, cross-dressing declined over time but was still conspicuous 8 weeks after transplantation. [The authors] conclude that crossdressing of host DCs with donor MHC molecules is a major antigen presentation pathway driving effector T cell responses within allografts."

Martin Oberbarnscheidt, MD, PhD • University of Pittsburgh, Pittsburgh, PA

Olivia Martinez, PhD • Stanford University, Stanford, CA

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