Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants

Recorded live on Thursday, January 19th, 2023, from 2:00 PM ET to 3:00 PM ET • Hosted by AST's Community of Transplant Scientists (COTS)

"Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants"
(J Clin Invest. 2022 Sep 1;132(17):e153403. doi: 10.1172/JCI153403.)

In this article:
Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts. Strikingly, barrier organs colonized with microbiota have significantly shorter half-lives than non-barrier transplanted organs, even in immunosuppressed hosts. [The authors] previously demonstrated that skin allografts monocolonized with the common human commensal Staphylococcus epidermidis (S.epi) are rejected faster than germ-free (GF) allografts in mice because the presence of S.epi augments the effector alloimmune response locally in the graft. Here, [the authors] tested whether host immune responses against graft-resident commensal microbes, including S.epi, can damage colonized grafts independently from the alloresponse... The dual effects of host-versus-commensal and host-versus-allograft responses may partially explain why colonized organs have poorer outcomes than sterile organs in the clinic.

- Isabella Pirozzolo • Columbia University Vagelos College of Physicians and Surgeons, New York, NY

- Maria-Luisa Alegre, MD, PhD • University of Chicago, Chicago, IL

- Andrew Wells, PhD • University of Pennsylvania, Philadelphia, PA

All AST Journal Clubs, and featured AST/AJT Journal Clubs, are free but registration is required to attend live.

Watch Video

Educational Content Disclaimer: The content, information, opinions, and viewpoints contained in educational materials housed on and linked from the AST web site are those of the authors or contributors of such materials. While the AST and its committees take great care to screen the credentials of the contributors and make every attempt to review the contents, AST MAKES NO WARRANTY, EXPRESSED OR IMPLIED, as to the completeness or accuracy of the content contained in the educational materials or on this website. The reader of these materials uses these materials at his or her own risk, and AST shall not be responsible for any errors, omissions, or inaccuracies in these materials, whether arising through negligence, oversight, or otherwise. Reliance on any information appearing on this site is strictly at your own risk. Read the full disclaimer.