Blocking CCL8-CCR8–Mediated Early Allograft Inflammation Improves Kidney Transplant Function

Thursday, April 6th, 2023, from 2:00 PM ET to 3:00 PM ET • Hosted by AST's Community of Transplant Scientists (COTS)

"Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function"
(J Am Soc Nephrol. 2022 Oct;33(10):1876-1890. doi: 10.1681/ASN.2022020139. Epub 2022 Aug 16.)

In this article:
In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions. [The authors found that] targeting the CCL8-CCR8 axis is a promising measure to reduce early kidney allograft inflammation.

- Xunrong Luo, MD, PhD, FAST • Duke University, Durham, NC

- Andrew Wells, PhD • University of Pennsylvania, Philadelphia, PA

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