Survival Benefit of Living-Donor Liver Transplant

Recorded live on Thursday, March 23rd, 2023 • Co-hosted by AST's Living Donor Community of Practice (LDCOP) and Liver and Intestinal Community of Practice (LICOP)

"Survival Benefit of Living-Donor Liver Transplant"
(JAMA Surg. 2022 Oct 1;157(10):926-932. doi: 10.1001/jamasurg.2022.3327.)

In this article:
Despite the acceptance of living-donor liver transplant (LDLT) as a lifesaving procedure for end-stage liver disease, it remains underused in the United States. Quantification of lifetime survival benefit and the Model for End-stage Liver Disease incorporating sodium levels (MELD-Na) score range at which benefit outweighs risk in LDLT is necessary to demonstrate its safety and effectiveness. [Based on a case-controlled study, the authors found a] LDLT is associated with a substantial survival benefit to patients with end-stage liver disease even at MELD-Na scores as low as 11. The findings of this study suggest that the life-years gained are comparable to or greater than those conferred by any other lifesaving procedure or by a deceased-donor liver transplant. This study’s findings challenge current perceptions regarding when LDLT survival benefit occurs.

For more information:
AST's Living Donor Community of Practice (LDCOP) has created a "Transplant Bytes" visual synopsis of the article to quickly summarize the content and help attendees prepare for the authors' presentations.

- Whitney Jackson, MD • University of Colorado Medicine, Aurora, CO
- John Malamon, PhD, MS • University of Colorado Medicine, Aurora, CO

- AnnMarie Liapakis, MD • Yale New Haven Transplantation Center, New Haven, CT
- Anjana Pillai, MD, FAST • University of Chicago Medicine, Chicago, IL

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