First clinical-grade porcine kidney xenotransplant using a human decedent model

Thursday, May 19, 2022 from 2:00 PM ET to 3:00 PM ET • Hosted jointly by AST's Education Committee and Kidney Pancreas Community of Practice (KPCOP)

"First clinical-grade porcine kidney xenotransplant using a human decedent model"
(Am J Transplant. 2022 Jan 20. doi: 10.1111/ajt.16930. Online ahead of print.)

In this article:
A radical solution is needed for the organ supply crisis, and the domestic pig is a promising organ source. In preparation for a clinical trial of xenotransplantation, [the authors] developed an in vivo pre-clinical human model to test safety and feasibility tenets established in animal models. After performance of a novel, prospective compatible crossmatch, [the authors] performed bilateral native nephrectomies in a human brain-dead decedent and subsequently transplanted two kidneys from a pig genetically engineered for human xenotransplantation.... [The] study suggests that major barriers to human xenotransplantation have been surmounted and identifies where new knowledge is needed to optimize xenotransplantation outcomes in humans.

Speakers:
- Paige Porrett, MD, PhD • University of Alabama at Birmingham, Birmingham, AL
- Jayme Locke, MD, MPH, FACS, FAST • University of Alabama at Birmingham, Birmingham, AL

Moderators:
- Andrew Adams, MD, PhD • University of Minnesota, Minneapolis, MN
- Burcin Ekser, MD, PhD • Indiana University, Indianapolis, IN

AST/AJT Journal Clubs are free, but registration is required.

Watch Video

Educational Content Disclaimer: The content, information, opinions, and viewpoints contained in educational materials housed on and linked from the AST web site are those of the authors or contributors of such materials. While the AST and its committees take great care to screen the credentials of the contributors and make every attempt to review the contents, AST MAKES NO WARRANTY, EXPRESSED OR IMPLIED, as to the completeness or accuracy of the content contained in the educational materials or on this website. The reader of these materials uses these materials at his or her own risk, and AST shall not be responsible for any errors, omissions, or inaccuracies in these materials, whether arising through negligence, oversight, or otherwise. Reliance on any information appearing on this site is strictly at your own risk. Read the full disclaimer.