Originally aired on Thursday, November 21st, 2019 • Hosted by the Live Donor Community of Practice (LDCOP)
"Impact of estimation versus direct measurement of predonation glomerular filtration rate on the eligibility of potential living kidney donors."
(Kidney Int. 2019 Apr;95(4):896-904. doi: 10.1016/j.kint.2018.11.029. Epub 2019 Feb 26.)
In this article:
While direct measurements of glomerular filtration rate (GFR) provide the most accurate evaluation of pre-donation kidney function, guidelines do not systematically require the use of a reference method. [The authors] evaluated whether and to what extent relying upon creatinine-based estimating equations (eGFR) rather than direct measurement of GFR (mGFR) alters the selection of potential living donors.... [The authors] conclude that creatinine-based estimates cannot substitute for direct GFR measurement to evaluate candidates for kidney donation. When reference methods for direct GFR measurement are not available, our data suggest that a strategy based on age-adapted eGFR values estimated with either the CKD-EPI or FAS equation should be preferred.
François Gaillard, MD, PhD • Hôpital Necker-Enfants malades, Assistance Publique-Hôpitaux de Paris, Paris, France
Edmund Huang, MD • Cedars-Sinai Medical Center, Los Angeles, CA