Transitional B cell cytokines predict renal allograft outcomes

Recorded live on Thursday, May 27, 2021 • Hosted by AST's Community of Transplant Scientists (COTS)

"Transitional B cell cytokines predict renal allograft outcomes"
(Sci Transl Med. 2021 Feb 24;13(582):eabe4929. doi: 10.1126/scitranslmed.abe4929.)

In this article:
[The authors] prospectively examined the ratio of interleukin-10 (IL-10) to tumor necrosis factor-α (TNFα) produced by transitional-1 B cells (T1B) 3 months after transplantation as a predictive biomarker for clinical and subclinical renal allograft rejection and subsequent clinical course... Among high-risk patients without early rejection, 74% developed rejection later in the first year. In contrast, only 5% of low-risk patients had early and 5% late rejection... Biomarker high-risk patients exhibited progressively worse renal function and decreased 5-year graft survival compared to low-risk patients. Treatment of B cells with anti-TNFα in vitro augmented the IL-10/TNFα ratio, restored regulatory activity, and inhibited plasmablast differentiation. [The authors concluded that] the T1B IL-10/TNFα ratio was validated as a strong predictive biomarker of renal allograft outcomes and provides a rationale for preemptive therapeutic intervention with TNF blockade.

- Aravind Cherukuri, MBBS, PhD, MRCP • University of Pittsburgh, Pittsburgh, PA

- Aman Bajwa, PhD • University of Tennessee Health Science Center, Memphis, TN
- Olivia Martinez, PhD • Stanford University, Stanford, CA

- David Rothstein, MD • University of Pittsburgh, Pittsburgh, PA

Watch Video

Educational Content Disclaimer: The content, information, opinions, and viewpoints contained in educational materials housed on and linked from the AST web site are those of the authors or contributors of such materials. While the AST and its committees take great care to screen the credentials of the contributors and make every attempt to review the contents, AST MAKES NO WARRANTY, EXPRESSED OR IMPLIED, as to the completeness or accuracy of the content contained in the educational materials or on this website. The reader of these materials uses these materials at his or her own risk, and AST shall not be responsible for any errors, omissions, or inaccuracies in these materials, whether arising through negligence, oversight, or otherwise. Reliance on any information appearing on this site is strictly at your own risk. Read the full disclaimer.