Epigenetic Modifications of Immune Cells and their Importance for Alloimmunity Webinar
September 12, 2018 from 02:00pm to 03:00pm EDT
Speaker: Andrew Wells, PhD • University of Pennsylvania and CHOP
Moderator: Jonathan Maltzman, MD, PhD • Stanford University
After participating in this webinar, the learner will be able to:
- Define epigenetics, outline basic concepts and processes.
- Outline examples of DNA methylation controlling T cell function.
- Outline examples of histone modifications controlling T cell function.
- Describe examples of epigenetic factors contributing to organ transplant rejection in rodent models.
- Describe a clinical example of epigenetic drug targeting in allogenic bone marrow transplantation to alleviate GVHD.
- Outline basic concepts in genomics and epigenomics.
- Describe 3-dimensional regulatory architectures of inflammatory genes in T cells.
- Discuss the use of 3D epigenomics to understand the basis of genetic susceptibility to inflammatory disease in humans.